Identification of Predictive Biomarkers of Response to HSP90 Inhibitors in Lung Adenocarcinoma

Heat shock protein 90 (HSP90) plays an essential role in lung adenocarcinoma, acting as a key chaperone involved the correct functioning of numerous highly relevant drivers this disease. To end, HSP90 inhibitors have emerged promising therapeutic strategies, even though responses to them been limited date. Given need maximize treatment efficacy, objective study was use isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic techniques identify proteins human adenocarcinoma cell lines whose basal abundances were correlated with response (geldanamycin radicicol derivatives). From profiles identified according response, relationship between lactate dehydrogenase B (LDHB) DNA topoisomerase 1 (TOP1) respect sensitivity resistance, respectively, geldanamycin derivatives is noteworthy. Likewise, rhotekin (RTKN) decaprenyl diphosphate synthase subunit 2 (PDSS2) resistance derivatives. We also inhibition p53 pathway by glucose deprivation. In contrast, arginine biosynthesis inhibitors. Further these outcomes could enable development strategies improve clinical efficacy patients adenocarcinoma.